Goldenseal (Hydrastis canadensis).Goldenseal is one of the most popular herbs sold on the American market and has recently gained a reputation as a herbal antibiotic and immune system enhancer. Traditionally used by American Indians for a plethora of ailments, it was not until the late eighteenth century that it attracted attention in England and America where its use grew to become an important article of commerce. It is believed that the high content of alkaloids gives Goldenseal its antibiotic, anti-infective and immune stimulating qualities.